ABSTRACT
OBJECTIVE: Identify risk factors for severe outcome in Mexican patients with COVID-19 in the population of Quintana Roo. MATERIAL AND METHODS: Study of 5,916 who met the criteria for suspected cases of COVID-19, 2,531 confirmed by qrTPCR-Sars-CoV-2 tests, of which 1,486 were positive, among which they were classified as hospitalized (severe COVID-19) and outpatients. Multivariate logistic regression analysis was performed to explore the factors associated with the severity of COVID-19 and death as clinical outcomes. The basic reproduction number (R0) was calculated Statistical analysis) Endorsement of the ethics committee 2301. RESULTS: SARS-CoV-2 positive patients presented a high prevalence of hypertension 29.1%, diabetes 23.5%, obesity 24%, and 48.5% have at least one chronic disease. There is a high risk of severity for COVID-19 in patients with diabetes OR=3.14, hypertension OR=1.88, obesity OR=1.68, kidney disease OR=3.2, older than 65 years OR=13.6 and men OR=1.7. These factors also increase the risk of death up to 7.7 times. The maximum R0 during the epidemic was 2.4. CONCLUSION: Liver and kidney disease, diabetes, hypertension, and obesity are significantly associated with severe COVID-19 and death.
ABSTRACT
The clinical features of Covid-19 have been described in adults and infants younger than 1 year of age, although there is little data on the characteristics and the potential of intrauterine transmission in newborns. A case of infection was identified in a baby born in Cancún Quintana Roo, in a regional hospital at the beginning of the epidemic. The patient did not require intensive care, nor were there any serious complications. The mother was infected with SARSCoV-2, showing mild respiratory symptoms. Although 10 mothers with symptoms of SARS-CoV-2 have been observed to date, only one case of a positive newborn has been identified in the hospital. In summary, newborns are susceptible to SARS-CoV-2 infection. The SARS-CoV-2 PCR-positive newborn had no symptoms, and so SARS-Cov2 may be considered less severe in neonates than in adults. Vertical intrauterine transmission in women who develop COVID-19 pneumonia is possible, although evidence is still lacking in Latin America and around the world.